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Saturday, March 31, 2018  |  Volume 10 / Number 6  |  A Production of the BioProcessing Journal
The Waterside Conference
Career Development
13th Annual Meeting
April 25–26, 2018
New Orleans, Louisiana USA
21st Annual Meeting
May 16–19, 2018
Chicago, Illinois USA
Protein Chromatography Course – Engineering Fundamentals and Measurement for Process Development and Scale-Up
May 27–June 1, 2018
Vienna, Austria
MSS 2018
Monolith Chromatography Summer School and Symposium
June 15–20, 2018
Portorož, Slovenia
HPLC 2018
July 29August 2, 2018
Washington, DC USA
XXVI Annual Congress
October 16–19, 2018
Lausanne, Switzerland
Suggested Reading
Gamma Irradiation of Animal Serum: Maintaining the Cold Chain Throughout the Process
By Sue Brown et al., TCS Biosciences Ltd.
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Products & Services
Large-Scale Minicircle DNA Vector Production

BIA Separations and RBPS Technology (RBPS) have signed a partnership agreement to provide scalable manufacture of minicircle DNA at high purity. The project combines BIA Separations’ monolithic purification tools with RBPS’ novel process for production of minicircle DNA — plasmid DNA with an optimized safety profile for application in gene delivery.

Minicircles are circular, covalently closed DNA units lacking plasmid-typical ‘backbone’ sequences, such as a bacterial replication origin or an antibiotic resistance marker. The smaller size of minicircles also extends cloning capacity and facilitates their delivery into cells. Minicircle DNA is therefore considered to be the safest and most efficient vector for gene transfer. The RBPS system removes the bacterial backbone sequences from producer plasmids with more than 99.5% efficiency.

For more information, please visit or

Comprehensive Toolkit for Exosome Research

AMSBIO’s exosome product range now includes everything needed to study and use exosomes. For high-quality exosome isolation, AMSBIO offers the ExoQuick family of reagents for ultracentrifugation-free isolation, ExoMAX Opti Enhancer to provide a rapid, easy way to prepare samples for density gradient-based exosome isolation, or Exo-FLOW products for IP- and FACS-based exosome isolation. To quantify the exosomes you’ve isolated, AMSBIO offers a range of options that meet most needs. For the fastest and most sensitive antibody-based quantitation, the ExoELISA™-ULTRA CD63 kit provides sensitivity down to 1–200 µg protein equivalent — and a fast, 4-hour workflow.

For even faster quantitation (20 minutes) that does not rely on antibody binding, the EXOCET™ kit provides direct measurement of the activity of a known exosomal protein, acetylcholinesterase (AChE). FluoroCet is a more sensitive version of EXOCET that relies upon fluorescence-based quantitation.

Tracking exosomes and their cargo is easy using AMSBIO Exosome labels that include ready-to-go Cyto-tracers, ExoGlow reagents, and XPACK lentivectors. To characterize exosomal RNA or proteins for biomarker profiling, AMSBIO also offers a range of intuitive, easy-to-use products. For more information, please visit
Career Development
Higher Order Structure
April 9–11, 2018
Providence, Rhode Island USA
CMC Strategy Forum Europe
May 14–16, 2018
Noordwijk, The Netherlands
Cell Culture Engineering XVI
May 6–11, 2018
Tampa, Florida USA
Vaccine Technology VII
June 1722, 2018
Mont Tremblant, Quebec, Canada
PREP 2018—31st International Symposium on Preparative and Process Chromatography
July 8–11, 2018
Baltimore, Maryland USA
Cell Culture-Based Viral Vaccines Course – Third Edition
September 18–21, 2018
Animal Cell Technology Course 2018 – Eighth Edition
September 23–27, 2018
Llafranc, Costa Brava, Spain
The 31st Annual and International Meeting
November 5–8, 2018
Tsukuba, Japan
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Banner description: Cultured melanoma cells.
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