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Wednesday, April 15, 2015  |  Volume 7 / Number 8  |  A Production of the BioProcessing Journal
Career Development
CMC Strategy Forum
Europe 2015
May 4–6, 2015
Copenhagen, Denmark
CMC Strategy Forum
Summer 2015
July 20–21, 2015
Gaithersburg, Maryland USA
Immunopharmacology - Vaccipharma 2015
June 14–19, 2015
Varadero Beach, Cuba
Preservation of molecular, cellular and tissue biospecimens
May 19-20, 2015
Minneapolis, MN USA
Suggested Reading
Using Product Lifecycle, Process Validation, and Quality by Design (QbD) Paradigms to Efficiently Take New Biopharmaceutical Products from Pre-IND to Commercial Manufacturing
By Mark F. Witcher, PhD, Integrated Project Services (IPS)
Sponsored Link

Single-use Clarification Systems for up to 2,000 Liters
Sartoclear Dynamics® is a new single-use technology for harvesting animal cell cultures with high cell densities. Consistent results, ease of use, enormous speed and flexible scalability are the key characteristics of this technology. Inspired by the plasma industry, Sartoclear Dynamics® is based on the principles of body feed filtration. The ready-to-use clarification system enables single-use processing up to 2,000 liters. As a result, it replaces centrifuges and the subsequent depth filters in a single step.

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Products & Services
Effective Surface Sterilization of Freeze Drying Equipment
SP Scientific has partnered with Bioquell to produce an off-the-shelf surface sterilization/decontamination system for SP freeze dryers.

Traditionally, freeze dryers have used steam for sterilization, which exposes them to many different stresses and strains. SP Scientific, in conjunction with Bioquell, has developed an equally effective and less expensive solution to perform surface sterilization/decontamination of freeze dryers using hydrogen peroxide vapor (HPV).

HPV is well established as a bio-decontamination agent. Bioquell’s HPV technology has been tested and proven effective against many organisms including bacteria, bacterial endospores, viruses, bacteriophage, fungi, nematodes, and protozoa.

Surface sterilization/decontamination using the HPV system is remarkably quick, enabling fast turnaround of your freeze dryer. The HPV system is easy to use and simply integrated with your SP Scientific freeze dryer without the need for excessive external piping or critical utilities that are commonly required to support steam sterilizers. Operating with automated gasing cycles ensures excellent process repeatability and consistency.

For more information, please visit
Peptide Sequence Database to Investigate T Cell Immune System
ProImmune has introduced a new antigen database service called ProSentium™, based on in vitro assay results using sequencing mass spectrometry. ProSentium data can show the precise peptide sequences from proteins of interest visible to the body’s own T cell immune system. The data collection covers many high value therapeutic targets and areas including the majority of licensed replacement factor proteins, including clotting factors and replacement enzymes.

Under an exclusive or non-exclusive license, the bespoke database service investigates and reports peptide hits against the ProSentium database for a customer’s specific protein or protein family of interest. Results are reported as overlapping nested peptide sets and provide statistically relevant antigen sequence data.
ProSentium data can be readily analyzed and reported, and is fully compatible with ProImmune’s in vitro assay services which can be combined to help investigators gain a more complete understanding of relevant immune responses at a molecular level.

For more information, please visit
Techno-Blast Masthead
HeLa cell spheroids were generated in a Nuclon™ Sphera round-bottom 96-well plates, transferred to 35 mm glass-bottom dishes from Nunc™ and imaged by confocal microscopy. Oxidative stress was measured by using CellROX® Deep Red stain from Molecular Probes® with nuclear counterstaining with NucBlue® Live Cell stain. No enhanced oxidative stress were observed in this control sample.

Courtesy of Thermo Fisher Scientific.

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Career Development
Centrifugal Elutriation- Utility in the Flow Cytometry Laboratory
April 28, 2015
11:00 am EDT
Annual BEBPA Bioassay Conference
September 23–25, 2015
Budapest, Hungary
ASGCT 18th Annual Meeting
May 13–16, 2015
New Orleans, Louisiana USA
PREP 2015—28th International Symposium on Preparative and Process Chromatography
July 26–29, 2015
Philadelphia, Pennsylvania USA
ISPPP 2015—35th Symposium and Exhibit on the Separation and Characterization of Biologically Important Molecules
July 29–31, 2015
Philadelphia, Pennsylvania USA
BPJ Publishing

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