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Wednesday, November 12, 2014  |  Volume 6 / Number 23  |  A Production of the BioProcessing Journal
Career Development
Senior Manager,
Quality Assurance
CMC Strategy Forum
Japan 2014
December 8–9, 2014
Tokyo, Japan
CMC Strategy Forum
and WCBP 2015
January 26–29, 2015
Washington, DC USA
Phacilitate Washington Bioleaders Forum 2015
January 26–28, 2015
Washington, DC USA
Techno-Blast Masthead
The aggregation wars have started. Break out the secret enzymes!

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Suggested Reading
Which Factors to Consider When Selecting an Analytical Method
for Cell Culture Fermentation: A Comparison
of Four Different Metabolic Analyzer Instruments
By Caitlin Kurtz, North Carolina State University, and John Paul Smelko, Biogen Idec
Products & Services
Endonuclease Enzyme for Biomolecular Purification Processes
DENARASE® endonuclease, offered by Sartorius Stedim Biotech, is a genetically engineered endonuclease from Serratia marcescens used in downstream purification processes of biological molecules. Because of its high activity and ease of use, DENARASE is often utilized in the production of viruses and virus-like particles. The enzyme can be added to the cell lysate to rapidly reduce the large amounts of host-cell DNA, and decrease viscosity, thereby rendering the subsequent unit operations like column chromatography and membrane filtration much more economical.

DENARASE is produced under cGMP conditions and exclusively licensed to Sartorius Stedim Biotech by c-LEcta GmbH. Its production is based on recombinant expression in a Bacillus species bacterium strain and is free of animal-derived compounds.

For more information, please visit
Three New Resins Available for Pre-Packed Chromatography Columns
EMD Millipore has announced the availability of three new chromatography resins for its Chromabolt® pre-packed columns. These pre-validated chromatography columns can come packed with either strong cation exchangers, weak cation exchangers, or strong anion exchangers, freeing up end-users’ time and resources by eliminating manual column packing and cleaning.

Designed for pilot and early clinical-scale manufacturing, the Chromabolt columns are now available packed with these three resins: Fractogel® EMD SE Hicap, Fractogel EMD COO(M), and Eshmuno® Q, in addition to the already available Eshmuno S, Fractogel EMD SO3, and Fractogel EMD TMAE Hicap.

For more information, please visit
Peristaltic Pump with Weight-Scale Integration
Harvard Apparatus has announced the new P-1500 Peristaltic Pump with Weight-Scale Integration, allowing users to dispense fluids based on units of weight. The peristaltic controller provides communication between the pump and the scale, allowing the pump to query the scale during operation for precise dispensing. The peristaltic controller contains an interface that is compatible with the Mettler Toledo XS series, Ohaus Defender 5000 series, and Ohaus Ranger series scales (sold separately).

The weight-scale capabilities of the P-1500 make it an ideal dispenser for reproductive biotechnology samples and organic solvents. Key features include anti-drip, auto-tare, and slow-down capabilities.

For more information, please visit
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Career Development
Technical Short Course:
Insect Cell Culture and Baculovirus Expression Vector System
March 31–April 3, 2015
Worcester, Massachusetts USA
BPJ Publishing

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