Wednesday, September 19, 2012  |  Volume 4/Number 19  |  A Production of the BioProcessing Journal

Career Development
Creating an Effective
Contamination Control
and Environmental Monitoring Program
September 27, 2012
10:00 AM EDT
Continuous Flow Chemistry
and Crystallization Development Symposium
September 26, 2012
New Brunswick, NJ USA
CE Pharm 2012:
14th Symposium on
the Practical Applications
for the Analysis
of Proteins, Nucleotides,
and Small Molecules
Sep. 30-Oct. 4, 2012
Scottsdale, Arizona USA
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Suggested Reading
Role of the Container/Closure System and Formulation on
Agitation-Induced Aggregation Phenomena in Recombinant Adenoviral Products
Maria A. Croyle, PhD et al., The University of Texas at Austin
Complex N-glycosylation of Recombinant Proteins by Insect Cells
Laura A. Palomares et al., Instituto de Biotecnologia, Universidad Nacional Autonoma de México
Products & Services
CYTOO’s 2D+ Cell Culture Platform Enables Quantitative Mapping of
Trafficking Compartments and Standardized Mitochondrial Analysis
CYTOO S.A.'s 2D+ Cell Culture Platform enables two new high content analysis (HCA) approaches: (i) quantitative density mapping of trafficking compartments and (ii) standardized mitochondrial analysis.

The CYTOO 2D+ Cell Culture Platform, which was launched in July 2012, is based on the use of adhesive micropatterns in microplate wells to guide the cell architecture and behavior in culture. By defining the 2D topology of cell adhesion, the 2D+ Technology enables the fine control of the spreading and 3D shape of cultured cells in single- or multi-cellular configurations resulting in control of cell contractility, cell polarity, organelle positioning, or cell division axis. This opens new perspectives for more physiologically relevant cell-based assays compared to classical 2D culture where cells spread and move in an uncontrolled manner.

For more information, please visit or
email Constantin Nelep, PhD at
Graver Introduces Sterilizing Grade ZTEC Membrane
Graver Technologies, LLC announces the release of the ZTEC P Sterilizing Grade filter cartridges, specifically intended for use in critical applications including the final filtration of therapeutics, vaccines, serums and cell culture media, and diagnostic reagents.

The new ZTEC P Sterilizing Grade filters utilize a double layer of PES membrane that has been specifically tested against the target organism Brevundimonas diminuta and validated through multiple lot testing to meet the requirements specified in ASTM 838-05 for sterile effluent. Each filter is 100% integrity tested, serialized, and comes with a certificate of conformance in the package. A validation guide is available upon request.

For more information, please visit, e-mail, or call +1 888-353-0303.
Bosch Introduces Newly Developed Capping Machine with Integrated Quality Test
Bosch Packaging Technology has developed a new sealing solution for injection and infusion vials: the compact VRT 1010|1020. The machine is equipped with highly sensitive control systems, ensures reliable capping and achieves an output of 120 containers per minute.

Depending on the version, the intermittent VRT 1010|1020 takes over the filled and plugged injection and infusion vials from an upstream filling machine or a rotary table via single or double lane. Before capping, a camera-based sensor performs the stopper presence check. The sealing machine is also equipped with a camera for best capping quality. A modern touch-screen allows for easy handling and enables the storage and full reproducibility of format specific settings.
Further control systems can be added to the VRT 1010|1020, which can also be combined with barrier and containment systems. The machine meets the current EU GMP requirements according to Annex 1.

For more information, please visit or email Dieter Bandtel at
Techno-Blast Masthead
Jurkat cells. YO-PRO®-1 dye and propidium iodide, components of the Membrane Permeability/Dead Cell Apoptosis Kit.

Copyright © 2012 Life Technologies Corporation ( Used under permission.

Email your cell images to the editor today!
  Career Development
2012 Mid-Atlantic Bio
September 27-28, 2012
Bethesda, Maryland USA
BEBPA Bioassay Meeting
September 26-28, 2012
Lisbon, Portugal
The 25th Annual and
International Meeting of the Japanese Association for Animal Cell Technology
November 27-30, 2012
Nagoya, Japan
Microbial Fermentation: Development & Scale-Up
October 16-19, 2012
Cell-Based Vaccine Production:
A Hands-on Approach

November 13-16, 2012
Both courses take place in:
Logan, Utah USA
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