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Thursday, March 8, 2012  |  Volume 4/Number 5  |  A Production of the BioProcessing Journal

Career Development
On-Demand Webcasts
Vaccines and Related Biological Products Advisory Committee Meeting
held on
February 28-29, 2012

Biosimilars – Understanding Regulatory Challenges
June 25-26, 2012
Los Angeles, California
European Filing and Registration Procedures
July 23-24, 2012
King of Prussia, Pennsylvania
Insights in Lyophilisation: Current Best Practices & New Research Trends
May 9, 2012
Basel, Switzerland
May 11, 2012
Stockholm, Sweden
May 14, 2012
Antwerp, Belgium
Phacilitate Immunotherapy Leaders' Forum 2012
May 9-11, 2012
Barcelona, Spain
Techno-Blast Masthead
Bovine Pulmonary Artery Endothelial Cells (BPAE Line) image provided by Michael W. Davidson, National High Magnetic Field Laboratory, The Florida State University, Tallahassee.

Email your cell images
to the editor today!
Suggested Reading
Analysis of the BPCIA, the Pre-Approval Patent Resolution Process,
Regulatory Exclusivity Periods, and Complementary Rules Affecting Patent Terms
(The Second of a Three Part Series)
By Verne A. Luckow, PhD, Polster Lieder Woodruff & Lucchesi, LC
Regulatory Aspects of Recombinant Protein Products by Baculovirus Expression Systems
By Daniel Galbraith, PhD, written while at Q-One Biotech Ltd.
Products & Services
Advanced Composite Purification Columns
BIA Separations has developed a new generation housing for CIM® monolithic ­resins. Now, customers have access to monolith technology in a multi-use disposable format with the quality, performance, and safety of stainless steel columns. CIMmultus™ advanced composite columns are suitable for purification of biologics in a single or multi-use mode. This gives process developers and manufacturers full flexibility as it can be economical in both modes. Single-use or multi-use? You decide!

The housings are coated with USP Class VI parylene C which
ensures exceptional chemical stability, surpassing the USP Class VI polypropylene housings. ­CIMmultus advanced composite columns offer safety, performance, and versatility. Find out more about CIMmultus columns at

For availability and prices please contact
Next Generation Microbial Colony Pickers
Molecular Devices, LLC has launched its QPix 400 series of microbial colony pickers enabling scientists to manage large, ­diverse populations with 98% efficiency in colony picking. Specific features such as: a unique pre-screening step that simultaneously detects colonies and quantifies fluorescent markers; highly accurate robotics; organism-specific colony picking pins; and an agar height sensor all combine to ensure that the colony of interest is objectively identified and selected every time.
The QPix 400 series applications include protein expression, biofuel research, enzyme evolution, phage display, DNA sequencing, and library generation and management. The QPix 460 is an advanced system ­offering complete automation workflow and the ability to transfer selected colonies to as many as 140 destination plates in two stacker lanes. The QPix 450 is partially auto­mated, from imaging to picking, and can transfer to up to 210 destination plates in three stacker lanes.

For more information on the QPix 400 series, visit
Automated DNA Monitoring During Manufacturing
Using the MagNA Pure LC 2.0 system from Roche, scientists have developed and validated an automated process for monitoring clearance of Chinese hamster ovary (CHO) cell DNA during the capture and polishing steps when processing therapeutic proteins and mAb drugs.

Automated DNA monitoring during manufacturing eliminates analytics bottlenecks during process development and routine testing. Automated DNA isolation using Roche’s MagNA Pure LC 2.0 system results in high DNA recovery rates, and subsequent highly sensitive qPCR with the LightCycler® 480 real-time PCR instrument. MagNA Pure LC DNA purification eliminates: a) manual dilution of high-protein and high-DNA loads; b) manual acidic sample neutralization; and c) manual carrier RNA addition. The MagNA Pure LC 2.0 system does not require manual sample preprocessing, additional proteinase K pretreatment, sample neutralization and dilution, or carrier RNA.

Please visit for additional product information.

FDA Basics Videos
  Join the Discussion
Have you ever compared Sf21 cells from different sources?
Join the discussion string “Amplification of P1 virus below 1 x 10^6 pfu/mL” to contribute your expertise.
  Career Development
Monolith Summer School and Symposium
June 1-6, 2012
Ajdovščina, Portorož, Slovenia
Microbial Fermentation: Development & Scale-Up
March 20-23, 2012
Techniques In Animal Cell Culture & Scale-Up Strategies
April 17-20, 2012
Gene Expression &
Microarray Analysis

June 18-20, 2012
All courses take place in:
Logan, Utah USA
Going Beyond CHO:
Next Generation
Production Systems

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