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Friday, October 07, 2011  |  Volume 3/Number 13  |  A Production of the BioProcessing Journal
This issue of the Techno-Blast really was sent from Istanbul by members of the production staff who are on a working vacation. Merhaba, n'aber?
Career Development
Mid-Atlantic Bio Symposium
October 12, 2011
Washington, DC USA
Microbial Fermentation: Development & Scale-Up
October 18-21, 2011
Logan, Utah USA
Sustainability Webinar
October 26, 2011
FDA and Industry Perspectives on New Challenges and Innovation
November 8-10, 2011 Mayaguez, Puerto Rico
The New ParadIgM – 
IgM from Bench to Clinic

November 15-16, 2011 
Frankfurt, Germany
Techno-Blast Masthead
Bovine Pulmonary Artery Endothelial Cells (BPAE Line) image provided by Michael W. Davidson, National High Magnetic Field Laboratory,
The Florida State University, Tallahassee.

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to request a copy
Suggested Reading
The NIAID/Vaccine Research Center Vaccine Pilot Plant:
Design Approaches for Containment and Compliance in a Multi-Product Facility
By Criss Tarr, ScD et al., SAIC-Frederick, Inc.
Scalability of a Disposable Bioreactor from 25L - 500L Run in Perfusion Mode
with a CHO-Based Cell Line: A Tech Review
By Leigh N. Pierce and Paul W. Shabram, written while at Arizeke Pharmaceuticals, Inc.
Sponsored Links
Vetter’s State-of-the-Art Chicago Facility is Fully Operational
Vetter’s first US facility, located at the Illinois Science + Technology Park in Chicago, is now fully operational. The 24,000-square-foot site includes microbiology and chemical analysis labs, material preparation and compounding functions, three cleanrooms for aseptic filling, and visual inspection.

The Chicago facility supports preclinical through Phase II compounds, and is the first to use Bosch’s new MHI 2020 B fully automated vial filler to run up to 10,000 liquid or 6,000 lyophilized vials per batch. Both automated and semi-automated units provide a 100 percent in-line check-weigh system, eliminating the need for sampling while increasing API yield.  The facility also uses exclusively disposable components in material preparation, compounding, and filtration areas, which eliminates the need for cleaning validation.

The Chicago site and its processes meet stringent FDA and EMA quality requirements, in addition to providing seamless product transfer to Vetter’s large-scale manufacturing facilities in Europe for Phase III and commercial manufacturing. For more information, please visit www.vetter-pharma.com.
Optimised Gene Delivery Solution for Hard-to-Transfect Cells
AMSBIO introduces GeneIn — a new, novel cationic transfection reagent specifically designed to transfect stem cells and primary cells. GeneIn is formulated from proprietary compounds that are chemically defined and are of animal-free origin, and has been tested on a wide range of commonly used cell lines. Operating over a wide dynamic range, GeneIn offers minimal optimization to achieve excellent expression results.

The GeneIn transfection reagent forms part of a range of stem cell qualified products, including leukemia inhibitory factor (mLIF) and fibroblast feeder cells, that offer reproducible performance and high consistency from lot-to-lot.

Comparative studies against other commercially available reagents show GeneIn to be superior in transfection efficiency with minimum cytotoxicity. For more information, please visit www.amsbio.com/stem-cell-transfection-reagent.aspx.

MicroCal VP-Capillary Differential Scanning Calorimetry Software
for Increased Productivity in Stability Studies
GE Healthcare announces the launch of MicroCal VP-Capillary Differential Scanning Calorimetry (DSC) software for the automated, high throughput analysis of changes in protein stability. This analytical system enables characterization of the stability of molecules in solution during pre-formulation and process development, as well as formulation of the final biopharmaceutical product.
The software provides a single, intuitive graphical user interface for selecting and entering all sample and experiment run parameters, and is available with all new MicroCal VP-Capillary DSC systems and as an upgrade for current users.

The MicroCal VP-Capillary DSC system works by determining the heat absorbed by the sample as the protein unfolds, giving a measure of thermal stability and an indication of long-term stability. The system allows the study of up to 50 samples per day with fully automated cell filling, injection, and cleaning functions. For more information, please visit www.microcal.com.
  2nd Annual Meeting
  April 2-4, 2012
Rosslyn, Virginia USA

  Followed by the
1st Annual Meeting on:
 April 5-6, 2012
Rosslyn, Virginia USA
  Mark Your Calendar:
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