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Call for Articles
Accepting Manuscripts
for the Winter 2009 Issue
and Beyond
Sneak Preview: Fall 2009 BioProcessing Journal
The Fall 2009 Issue
has been finalized.

View it now on
our "preview" website.
Preparation of Haemagglutinin-IgG1 Fc Fusion Proteins in Insect Cells and Evaluation as Influenza Vaccines
TAG Xenograft Vaccine:
Xenograft-Expanded Autologous Tumor Vaccine Genetically Modified to Express GM-CSF and Block Production of TGFß2
Reference Materials
Adeno-Associated Virus (AAV2)
Reference Material Released

Characterization work has been completed for a new viral gene vector reference material. Using helper virus–free transient transfection, this AAV2–green fluorescent protein (AAV2-GFP) viral vector was derived from the vector plasmid pTR-UF-11. It is intended for use in validating internal reference materials and assays for viral gene products with the purpose of making data from different vectors more comparable.

Both the reference material and the plasmid will be available within a few weeks from ATCC for a nominal cost (product numbers VR-1616 and MBA-331 respectively). Each vial of the reference material contains 0.5 mL at a target dose of 1 × 10E11 vg.

With an NIH grant and donations from industry and numerous academic organizations, this material was produced and purified by a group led by Richard Snyder, PhD ( at the Vector Core of the University of Florida’s Powell Gene Therapy Center.

Two AAV Articles Co-Authored by Dr. Snyder:

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Your Contributions

Please submit materials via email to, but be sure to zip the file if it exceeds 2 MB. Another option is to mail us the file on a key drive, but note that we won’t return your drive since we collect them and it isn’t worth the handling cost.

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Blasts From the Past
To view prior Techno-Blasts,
go to our archives.
Headlines and links will take you to various postings on our site, and when appropriate, to the sites of various contributors. Postings will include articles, presentations, assays, techniques, protocols, blog chats, reviewer comments, product tutorials, virtual tours, application data, and pretty much any other form of online material that's needed to develop and produce safe and effective products.

Our initial focus will be on the toughest applications which tend to receive very little coverage elsewhere, such as viral gene vectors and cellular products. But as things progress and interest is expressed, we'll be adding Development Groups to cover applications such as vaccines, antibodies, recombinant proteins, and tissue regeneration.

Each Technology and application will have its own Development Group with one or more Reviewers and numerous contributors.


» Viral Vectors
» Cellular Products
» Safety and Efficacy
» Cell Banking
» Vaccines
» Antibodies
» Recombinant Proteins
» Facilities
» Quality Systems

Technologies will include essentially all the unit operations and support functions involved in bioprocessing, such as cell engineering and banking, cell culture scale-up, filtration, purification, media development, assay development, regulatory affairs, and facility design.
Content formats will include streaming video, YouTube postings, automated PowerPoint presentations--and of course--PDF, HTML, Word, and Excel docs.

We will be posting valuable information from key technology supply firms. As with our other primary content, these postings will have been assessed for their balance and credibility, and will include application data, tutorials, articles, presentations, and case histories.

Then in our Supplier-Side column, we will post materials with clear commercial content such as infomercials, ads, press releases, and promotions. And while some of these will be sponsored postings, other valuable resources will appear with no strings attached.