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Techno-Blast
Wednesday, February 15, 2017  |  Volume 9 / Number 4  |  A Production of the BioProcessing Journal
ISBioTech 7th Spring Meeting
Job Posting
GlycoBac
Research Scientist
Career Development
Disposable Solutions
Disposable Solutions for Biomanufacturing
February 27–March 1, 2017
Munich, Germany
International Serum Industry Association
12th Annual Meeting
May 3–4, 2017
Hong Kong
CASSS
Bioassays 2017:
Scientific Approaches & Regulatory Strategies
May 8–9, 2017
Silver Spring, Maryland USA
ASGCT
20th Annual Meeting
May 10–13, 2017
Washington, DC USA
25th ESACT Meeting
25th ESACT Meeting
May 14–17, 2017
Lausanne, Switzerland
ISBioTech 5th Fall Meeting
Suggested Reading
FDA GUIDANCE AGENDA: Guidance Documents CBER is
Planning to Publish During Calendar Year 2017
Products & Services
New Liquid Handling Platform Reduces Assay Development Time
and Improves Assay Robustness in High-Throughput Screening
TTP Labtech Ltd has premiered its dragonfly® discovery liquid handling technology, building on the success of the first dragonfly liquid handling platform, dragonfly crystal. The new dragonfly discovery is poised to address the complexities of assay development and the challenges associated with validation and subsequent transfer of those assays into high-throughput screening (HTS). This novel, user-friendly, low-volume liquid handling technology significantly reduces assay development time and greatly improves assay robustness in screening. The dragonfly discovery provides scientists with a standard platform whereby they can easily develop complex assays and screen those assays in a robust and cost-effective manner.
The new platform enables rapid and reliable low volume (200 nL and upwards) dispensing from a positive displacement disposable pipette (with 4 mL capacity), and 96, 384, and 1536 well-compatibility to allow assays to be developed directly in high density plate format using a common liquid handling platform. The same platform can also perform assay validation and subsequent HTS. In addition, a new user interface and software capability support the design and development of complex assays.

For more information, please visit ttplabtech.com.
dragonfly® discovery
New Multicolumn Continuous Chromatography Platform
Semba ProPD™ and Semba ProGMP™ Systems
Semba Biosciences introduces its versatile and easy-to-use multicolumn continuous chromatography platform for process development and GMP-compliant, single-use manufacturing. Many of the latest drug candidates are antibodies and other proteins which are extremely expensive to produce, in large part due to the chromatography steps required for their purification. Semba’s continuous chromatography technology reduces the cost of these steps by as much as 80%.

Semba ProPD™ and Semba ProGMP™ Systems convert inefficient batch protocols to highly productive continuous processes, while also improving product quality and consistency. The patented valve technology supports high flow velocities to maximize productivity and dramatically reduce chromatographic media costs. The control system enables seamless transfer from process development to manufacturing, which saves time when scaling up. The single-use flow path on the ProGMP System eliminates the need for cleaning and validation between runs.

For more information, please visit sembabio.com.
Next Generation of PAT Control System
After the success of PATfinder, BIA Separations improved the in-process control system and is now introducing PATfix™, which upgrades PATfinder features for robust bioprocess development. The high metabolic burden during recombinant protein production in E. coli bacterium can lead to cell death, consequent lysis, and an increase in impurities, as well as undesired product loss. Fast and precise analyzers to monitor E. coli bioprocesses and retrieve key process information, such as the optimal time point of harvest, may facilitate key decision making and enable better control to establish more robust bioprocesses.

The HPLC fingerprinting approach utilizes the whole chromatogram as the fingerprint, rather than a single peak. The integrated multivariate data analysis (MVDA) tools point out deviations from the optimal process. Such an impurity monitoring approach enables reliable at-line detection of physiological events in the bioreactor, while the need for cumbersome offline analytics is minimized. 

For more information, please visit biaseparations.com.
PATfix™
Career Development
PREP
30th International Symposium on Preparative and Process Chromatography
July 16–19, 2017
Philadelphia, Pennsylvania USA
BioProcess Cuba
BPJ Publishing
Now Offers Open Access
BioProcessing Journal BioProcessing Journal
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