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Techno-Blast
Thursday, October 13, 2016  |  Volume 8 / Number 21  |  A Production of the BioProcessing Journal
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Career Development
ISBioTech 7th Spring Meeting
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CMC Strategy Forum
Japan
December 5–6, 2016
Tokyo, Japan
BioProcess Cuba
Suggested Reading
WHITE PAPER
Operator Safety in Biopharmaceutical Manufacturing:
The Role Raw Material Suppliers Can Play
in Contributing to a Safer Production Environment
By James Grobholz, MilliporeSigma
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Products & Services
qEVsingle SEC Columns for Analytical Scale Exosome Isolation and Clinical Studies
Izon Science introduces a new analytical-scale exosome isolation column, the qEVsingle. Based on size-exclusion chromatography (SEC), the qEVsingle is designed to handle 100 µL samples of biological fluids (blood plasma or serum, cerebrospinal fluid, saliva, urine, etc.) or concentrated cell cultures. Designed for single use, the qEVsingle is ideally suited to large clinical studies involving hundreds or thousands of patient samples thanks to its fast operation and its ability to prepare protein contamination-free exosomes.
SEC columns, built to quality standards, provide the only separation method that can be standardized sufficiently for medical trials and subsequent clinical use. qEVsingle columns are expected to rapidly become the global standard for the diagnostic development of extracellular vesicles.

The qEVsingle completes the Izon Science range of exosome isolation SEC columns initiated by the successful standard qEV SEC column, which is designed for preparative-scale (500 µL samples) and can be used up to five times. For more information, please visit izon.com.
qEVsingle
Upgraded Automatic Filling System Offers Faster Set-Up and Increased Flexibility
A new and enhanced version of the Flexicon FlexFeed20 (FF20) automatic vial and bottle filling system is now available from Watson-Marlow Fluid Technology Group. The system includes a host of newly developed features designed to offer improved flexibility, faster set-up, and greater protection from contamination of open vials/bottles.

Users of the latest iteration of the FF20 will find that bottle sizes from 12 mm/0.47” to 78 mm/3.07” diameter can now be accommodated. The FF20 can now also be set up in less than two minutes, with no tools, format parts, or special skills required. The speed at which the vials or bottles are presented at the filling needle in an FF20 is fully adjustable, allowing lightweight vials or bottles to be filled.
Flexicon FlexFeed20
The new system is easier to use thanks to the introduction of an intuitive, icon-based human-machine interface (HMI) on the front of the unit. Settings can easily be adjusted while simultaneously preventing contamination of open bottles.

The FF20, used in conjunction with a Flexicon peristaltic filler and crimp or screw capping machines, provides a simple, modular, and very flexible means of production. For more information, please visit wmftg.com.
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Techno-Blast Masthead
Human adipose stromal cells (passage 3) derived from lipoaspirate were grown in adipogenic conditions and then fixed, stained with Oil Red O, and counterstained with hematoxylin. Round lipid vesicles are seen in most cells. Total magnification of image is 200X.
Courtesy of Coriell Institute for Medical Research
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