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Techno-Blast
Thursday, September 29, 2016  |  Volume 8 / Number 20  |  A Production of the BioProcessing Journal
Lonza
BioBLU
Career Development
WuXi Biologics
Webinar:
New Process Development Workflow Shortens Timelines Enabling Rapid Scale Up
October 20, 2016
Cell and Gene Therapy
ESGCT Annual Meeting
October 18–21, 2016
Florence, Italy
ISPPP
ISPPP2016
November 6–9, 2016
Salzburg, Austria
JAACT
The 29th Annual and International Meeting
November 9–12, 2016
Kobe, Japan
BioProcess Cuba
Suggested Reading
Using a Patient-Centered Risk-Benefit Structure and Appropriate
Manufacturing Practices (AMPs) for Successfully Developing
and Manufacturing Effective Cell Therapy Products
By Mark F. Witcher, PhD, NNE Pharmaplan
Sponsored Link
Cadence™ Inline Concentrator
Cadence™ Inline Concentrator: Single-pass TFF Process
Providing Novel Facility Fit Solutions for Continuous Processing
Single-pass Tangential Flow Filtration (TFF) technology is becoming today’s standard for biomolecules concentration. It is the professional’s choice for biotech downstream processing (DSP). With Pall Life Science’s Cadence Inline Concentrator, TFF just got a whole lot easier.
Highly productive TFF process with the simplicity of direct flow filtration (DFF)
In-process volume reduction of 2x–4x and higher
Pre-assembled, holder-less, plug & play module for process integration
Reduced residence time to minimize product shear
Pall Life Sciences
Email: biopharm@pall.com
www.pall.com/continuous
Products & Services
3D Mitochondrial Toxicity Testing Service
InSphero AG has launched a new service, 3D InSight™ Mitochondrial Toxicity Testing, for the identification of mitochondrial liabilities during drug development and safety testing. Mitochondrial toxicity is a major adverse mechanism of toxicity for many drugs assigned black box warnings. When cells encounter stress, such as exposure to toxic drugs, they utilize reserve respiration capacities, which are quantified in the assay as spare respiratory capacity (SRC). A decrease in SRC is one of the first detected consequences of mitochondrial impairment, and the assay compares dose-dependent changes in SRC and cellular viability to assess the likelihood a drug will impair mitochondrial function.
The new service combines the organotypic liver functionality and 28-day in vitro lifespan of 3D InSight Human Liver Microtissues with state of the art analysis of mitochondrial respiration using the Agilent XFe96 Analyzer. The long-term metabolic competence of 3D liver microtissues enables flexible drug exposures of up to 14 days, while the XFe96 Analyzer allows assessment of mitochondrial function through sensitive and precise measurement of cellular oxygen consumption rate (OCR) on a single microtissue level.

For more information, please visit insphero.com.
3D InSight™ Mitochondrial Toxicity Testing
Modernizing Pharmaceutical Cold Chain Monitoring
Onset is expanding the InTemp family of pharmaceutical cold chain management products with the launch of two new solutions: InTemp CX500 Series temperature loggers and the InTempConnect cloud-based data warehousing service. Together with Onset’s proven CX400 Series loggers and InTemp mobile application, the solutions provide end-to-end visibility throughout the pharmaceutical supply chain.
InTemp
Bluetooth Low Energy (BLE) enabled InTemp CX500 Series loggers provide in-transit temperature monitoring, offering a cost-effective alternative to global positioning system (GPS) based solutions, and automatically transmit mission-critical temperature data to smartphones and tablets.

The InTempConnect cloud-based data warehousing service enables command-center control over all logger deployments throughout the global supply chain. And like all InTemp products, the new solutions achieve 21 CFR Part 11 compliance, ensuring electronic records and electronic signatures are trustworthy and reliable.
The free InTemp mobile app works with all Android and iOS mobile devices. Authorized users can easily view data from the loggers, check logger status, set alarms, and create and share secure PDF reports from their mobile devices. For more information, please visit onsetcomp.com/intemp.
Career Development
ISBioTech 4th Fall Meeting
CASSS
CMC Strategy Forum
Japan
December 5–6, 2016
Tokyo, Japan
BPJ Publishing
Now Offers Open Access
BioProcessing Journal BioProcessing Journal BioProcessing Journal
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Techno-Blast Masthead
Human adipose stromal cells (passage 3) derived from lipoaspirate were grown in adipogenic conditions and then fixed, stained with Oil Red O, and counterstained with hematoxylin. Round lipid vesicles are seen in most cells. Total magnification of image is 200X.
Courtesy of Coriell Institute for Medical Research
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