Wednesday, September 4, 2013  |  Volume 5 / Number 18  |  A Production of the BioProcessing Journal
Career Development
Applied Principles and Techniques for Depth Flow (DFF) and Tangential Flow (TFF) Filtration
October 8-11, 2013
Worcester, MA USA
CMC Strategy Forum
Japan 2013
December 9-10, 2013
Tokyo, Japan
6th Monolith Summer
School & Symposium
May 30-June 4, 2014
Portorož, Slovenia
Suggested Reading
Adventitious Virus Contamination Testing: Massively Parallel Sequencing in
a Multimodal Solution for Biopharmaceutical Safety Testing
Corresponding Authors: Jeffrey A. Shaman, PhD, GENEWIZ, Inc.
and Michael J. Hantman, PhD, Charles River Laboratories
Products & Services
Automated System for Drying or Concentrating Large Solution Volumes
Genevac, a division of SP Scientific, has introduced the ROCKET 4D – a fully automated evaporation system for drying or concentrating large solution volumes (up to 100 liters) in one operation with no user interaction.

The ROCKET 4D incorporates a proprietary vacuum technology to suppress solvent bumping and foaming. The system automatically feeds the solution into the evaporation vessel, controls temperature and pressure, and drains the condenser when necessary. The system stops when the product is dry or sufficiently concentrated. If required, the system will automatically redissolve the product in a small volume of solvent. Rocket 4D offers fast, safe evaporation for solvents with a boiling point of up to 165°C and can dry aqueous samples.

For more information, please visit genevac.com/Rocket4D.
Transgenic Rodent Mutation (TRM) Assay Service
BioReliance®, a unit of SAFC®, announced its Big Blue® Mouse Transgenic Rodent Mutation (TRM) assay has met the Organization for Economic Co-Operation and Development (OECD) Test Guideline 488 requirements for evaluating in vivo mutagenicity. This assay utilizes a novel transgenic mouse model specifically bred for use in the assay. It is recommended by various agencies and expert groups, including the European Chemicals Agency, as an accepted assay for evaluating mutagenicity in somatic and germ cell tissues. The assay service provided by BioReliance offers pharmaceutical and chemical companies a confirmatory test for drugs and chemicals that initially tested positive in in vitro mutation assays.

For more information, please visit bioreliance.com.
Reference Pipette
Eppendorf has introduced the new Reference® 2 pipette, the successor to the Reference pipette. The new design weighs less and requires less operating forces while providing accurate results, reliable handling, and user safety. The Reference 2 offers traceability through the use of an embedded RFID chip containing all of the instrument’s relevant data, including serial number and certificate of conformity. Furthermore, a serial number is printed on multiple components of the pipette to guard against volume defining parts from being accidently interchanged during reassembly. The incorporation of one-button technology and a spring loaded tip cone design allows for quick tip ejection and less aerosol creation. The design also reduces repetitive strain injury by eliminating the need for sideways thumb motion. The Reference 2 pipette is available in single and multi-channel models.


For more information, please visit reference2.eppendorf.com
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Career Development
The Preservation of Cellular Therapy Products:
An Interactive
Collaborative Workshop
October 10-11, 2013
Denver, CO USA
BPJ Publishing