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Thursday, May 3, 2012  |  Volume 4/Number 9  |  A Production of the BioProcessing Journal

   
Career Development
Scalable Transient
Mammalian Expression
System Based on
BacMam Technology

Webinar: May 9, 2012
Presented By
Kempbio, Inc.
White Paper
Next Steps
in Enzymatic Catalysis

Applying QbD Principles
in Vaccine Development: PDA/FDA CMC Workshop
May 14, 2012
Bethesda, Maryland USA

Techno-Blast Masthead
Epithelial Cells

Image provided by
Michael W. Davidson,
National High Magnetic Field Laboratory, The Florida State University, Tallahassee.

Email your cell images
to the editor today!
Suggested Reading
A Rapid Method for the Capture and Purification of a Protease Sensitive Protein
By Christopher W. Kemp, PhD, written while at Kemp Biotechnologies, Inc. (now with Kempbio, Inc.)
Development of Capabilities for Small-Scale Virus Fills
By Joseph Senesac et al., written while at Introgen (now with Bellicum Pharmaceuticals)
Sponsored Link
New Disposable Chromatography Housings from BIA Separations

These epoxy, thermoset-composite housings are carbon fiber-reinforced to provide the strength of stainless steel at a cost that makes them ideal for single-use or multi-use disposable applications. The product contact surfaces are coated with USP Class VI Parylene C which surpasses other polymer housings for chemical stability.

CIMmultus™ columns, available in 1 mL to 8000 mL volumes and pre-packed with CIM® monolithic resins, are the best choice for the purification or removal of viruses, plasmid DNA, protein aggregates, and macromolecules; as well as smaller molecules in a flow-through / polishing mode.


For more information, please go
to our website at CIMmultus™
advanced composite columns.
Products & Services
Filter Integrity Testing at Its Most Sophisticated Level
Sartorius Stedim Biotech introduces the newly developed Sartocheck 4 plus. An optional scanner now enables Sartocheck 4 plus to automatically capture data matrix code on the respective filter cartridges, such as filter type, lot number, and date of expiration. Immediately after the data of a filter cartridge have been scanned in, the integrity test system automatically selects the appropriate test program from its database.

For more information,
please visit www.sartorius.com.
Units additionally connected to the Sartocheck 4 plus, called “MultiUnits,” permit users to run independent parallel tests of up to five different filters. The Sartocheck 4 plus offers a wide choice of electronic data transfer options and can be completely interfaced with the appropriate process control systems for automatic control of integrity testing.

The patented cleaning function of the integrity test system enables reliable sanitization of the internal pneumatic components, even after aggressive cleaning agents (up to 1 M NaOH) have been used. This one-of-a-kind feature, combined with the option of using external vent valves, results in maximum reliability during filter integrity testing.
Easy Connect Capsule Filters
ZenPure has developed a click and lock capsule filter that connects to a disposable system, machine, instrument, tube set, bio-container — even a bioreactor — with one simple action: push and fit. The SKS filter modifies the flow geometry from traditional ‘T’ and ‘Inline’ to ‘U’. This makes capsule assembly and disassembly smooth and easy in one plug-and-play movement.

The ports, including three male quick couplers mated with three female receptors bracketed to the vent, process inlet, and filter outlet parts of the assembly, run in parallel at the top of the filter capsule. The capsule can be equipped with an optional upstream-side down tube for dispersing fluids evenly across the filter surface. Filters can also be equipped with a RFID for recording installation, usage cycles, integrity test, or traceability for production batch records.

Simple to use, reduced assembly times, leak-free, and sanitary, the SKS makes capsule connecting easy, reliable, and fast with fewer accessories.
For more information, please visit www.zenpure.com.
  Career Development
Phacilitate Immunotherapy Leaders' Forum 2012
May 9-11, 2012
Barcelona, Spain
Microbial Fermentation: Development & Scale-Up
May 22-25, 2012
Gene Expression &
Microarray Analysis

June 18-20, 2012
Downstream Processing of Biotechnology Products
September 11-14, 2012
All courses take place in:
Logan, Utah USA
BPJ Publishing
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