Thursday, June 23, 2011  |  Volume 3/Number 6  |  A Production of the BioProcessing Journal

Career Development
2011 BIO International Convention
Schedule a meeting with
BioProcessing Journal
June 27-30, 2011
Washington, DC USA
ISBioTech members receive 10% off the registration.
Protein Expression in Animal Cells Conference
September 25-29, 2011
Cascais, Portugal
ASGCT NIH
Gene Therapy Symposium

September 26-27, 2011
Bethesda, Maryland USA
Workshop:
The New ParadIgM –
IgM from Bench to Clinic

November 15-16, 2011
Frankfurt, Germany
Suggested Reading
Adventitious Viral Contamination of Biopharmaceuticals: Who is at Risk?
By Raymond Nims, PhD, RMC Pharmaceutical Solutions, Inc.
Understanding the Fundamentals of Peptides and Proteins
By Gary Hu, American Peptide Company
Sponsored Links
Pall Allegro Single-Use Mixer Improves BioPharm Process Efficiency

Pall Corporation introduces the Pall Allegro 200L Single-Use Mixer for high-performance mixing in biopharmaceutical applications from pilot scale to full production. This latest addition to the extensive portfolio of Pall Allegro single-use solutions and services substantially improves the efficiency of critical mixing processes throughout the drug production cycle.

The Allegro 200L mixer is designed to provide exceptional mixing performance for a wide range of liquid-liquid and solid-liquid mixing applications, including compounding, formulation, buffer and media preparation, and pH/conductivity adjustment. It is especially engineered for difficult mixing applications, including processes utilizing dense powders or high viscosities, or applications requiring repeatable, fast-mixing performance.
The Pall Allegro platform provides a complete range of single-use processing solutions, technical support, and validation services to support all biopharmaceutical development applications from upstream through downstream as well as formulation and filling. The high-performance Allegro 200L Single-Use Mixer further strengthens Pall’s growing portfolio of single-use total fluid management solutions by simplifying qualification and validation requirements, and streamlining implementation.

UAB First in US to Acquire a Cell-Processing Workstation from SANYO

The University of Alabama at Birmingham has taken a significant step toward making sophisticated cell therapy a part of patient care with its acquisition of the first cell-processing workstation (CPWS) in the United States from SANYO North America Corporation.

The CPWS, a piece of equipment about the size of a small car, contains all the necessary equipment required to manufacture cells for cell therapy in a sterile environment. It is, says Larry Lamb, PhD, director of UAB's Cell Therapy Lab, "like a clean room in a box. It provides bio-containment that's ideal for keeping a cell product sterile and stable, which is especially important if the cells need to be cultured for a long period of time or require several manipulations."
According to SANYO, the CPWS is considered the industry's first integrated, stand-alone solution for GMP-compliant processing and manufacture of regenerative stem cell and cell therapies for research applications. The workstation provides the required class-100 aseptic environment in a compact footprint and at a lower cost than a traditional cleanroom. The CPWS installed at UAB is a positive pressure system.
BioTek Introduces the World's First Deep Well Microplate Washer

BioTek Instruments, Inc.
continues to set new standards in microplate washers with the launch of the ELx405 Select Deep Well Washer. The new ELx405 Select Deep Well Washer is a robot compatible, full plate washer for automated aspirate and dispense steps in 96- and 384-well plates up to 50 mm high, and can also accommodate standard 15 mm microplates. This delivers increased washing efficiency compared to manual and hand-held methods.

The ELx405 Select Deep Well Washer also features BioTek's patented Dual-Action manifold for independent and precise aspirate/dispense control, and variable flow rates and angled dispensing for optimized cell washing. Washing protocols may be created and run through the familiar keypad interface or through BioTek's LHC Software. Additionally, optional Ultrasonic Advantage integrated ultrasonic cleaners provide manifold self-maintenance, and optional automatic 1-to-4 wash buffer switching further enhances efficiency.

Typical applications that can now be automated include: plasmid DNA purification, serum/plasma sample preparation, hematopoietic progenitor cell enumeration and cell proliferation assays.
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  This summery image is a representative optical micrograph depicting primary smooth muscle cells post-treatment to cell electrospinning at a time point of three weeks.
Image courtesy of
Suwan N. Jayasinghe, PhD, University College London, Department of Mechanical Engineering.

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the editor today!